Technology Behind
A Synergistic Complex Targeting Energy, Vascular Function & Absorption
CardioActive® is a scientifically optimized blend combining CoQ10, Green Tea Extract, and Black Pepper Extract (Piperine) to support cardiovascular energy, antioxidant protection, and nutrient absorption. This trio works synergistically to enhance ATP production in heart cells, improve endothelial function, and increase bioavailability of key nutrients.
CoQ10 fuels mitochondrial energy production, Green Tea Extract provides vascular and antioxidant support through EGCG and chlorogenic acids, while Piperine boosts absorption and prolongs active ingredient retention.
A synergistic trio for maximum cardiovascular support:
- CoQ10 for heart energy
- Green Tea Extract for vascular performance
- Piperine to enhance absorption
Key Challenges
Low CoQ10 and polyphenols (EGCG, catechins) absorption due to poor solubility
Inflammation and oxidative stress harming endothelial cells
Poor synergy in conventional multivitamin blends
Reduced mitochondrial energy production in aging and cardiac patients
Extracts Molecular Engineering
CardioActive® is the result of deliberate molecular formulation engineering where:
- CoQ10 (≥98%) was selected for mitochondrial efficiency and antioxidant protection. Its high purity ensures therapeutic relevance, even at modest dosing.
- Green Tea Extract was standardized not only for EGCG (~60–70% of catechins) but also for chlorogenic acid (~10%) — combining vasoprotective and anti-inflammatory actions in one botanical matrix.
- Black Pepper Extract, a high-ratio extract (25:1), was incorporated with 10% Piperine to boost intestinal absorption, prolong plasma life, and reduce enzymatic degradation of both polyphenols and CoQ10.
A Synergistic Complex Optimized for Heart Energy & Vascular Function
CardioActive® is a scientifically formulated blend of CoQ10, Green Tea Extract, and Piperine, designed to deliver synchronized energy, antioxidant protection, and enhanced nutrient uptake. It directly supports cardiovascular function, reduces oxidative stress, and improves the absorption of critical nutrients.
- Multimodal targeting — mitochondria + endothelium + gut absorption
- Balanced ratio for metabolic and absorption synergy
- Solvent-safe extraction — Water and ethanol only, no harsh solvents or carriers
How CardioActive® Works?
- CoQ10: Enhances ATP generation in cardiomyocytes and protects against oxidative damage.
- Green Tea Extract (EGCG): Improves endothelial function, supports healthy blood pressure, and reduces inflammation.
- Piperine: Boosts absorption of CoQ10 and polyphenols, increasing their systemic availability.
Cardiac Performance
Supports cardiac energy and performance
Super Effect
Enhances vascular flexibility and function
Healthier Heart
Promotes healthy blood pressure and lipid profiles
Pharmacokinetics
The CardioActive® Blend (CoQ10 + Green Tea Extract + Piperine) exhibits enhanced pharmacokinetic behavior through synergistic absorption enhancement, mitochondrial targeting, and metabolic pathway modulation.
A. CoQ10 Pharmacokinetics (Improved by Piperine)
Absorption
- CoQ10 normally has poor solubility; with Piperine, intestinal permeability increases significantly.
- Piperine inhibits P-glycoprotein efflux pumps, increasing CoQ10 uptake and Cmax.
Distribution
- CoQ10 is incorporated into lipoproteins and transported preferentially to cardiac and skeletal muscle mitochondria.
- Piperine extends circulation time by reducing hepatic clearance.
Metabolism
- Piperine suppresses CYP3A4-mediated metabolism, ensuring that a greater proportion of CoQ10 reaches systemic circulation unchanged.
Elimination
- Reduced metabolic breakdown leads to a higher AUC and slower elimination curve.
B. Green Tea Extract (EGCG) Pharmacokinetics
Absorption
- MolecuMix®-facilitated dispersion improves solubility of EGCG.
- Piperine enhances intestinal uptake and slows glucuronidation.
Distribution
- EGCG has strong affinity for vascular endothelium, liver, intestinal mucosa, and cardiac tissues.
Metabolism
- Piperine inhibits UDP-glucuronyl transferase, reducing EGCG Phase II conjugation.
- This prolongs the half-life of active catechins.
Elimination
- Delayed clearance and higher systemic exposure due to reduced conjugate formation.
C. Piperine Pharmacokinetics (Bioavailability Enhancer)
Absorption
- Rapid absorption through passive diffusion.
- Reaches peak concentration quickly, enabling immediate enhancement of other actives.
Distribution
- Distributes widely into intestinal tissues and hepatocytes.
Metabolism
- Inhibits several metabolic enzymes, enabling nutrient-sparing and bioavailability-enhancing effects.
Elimination
- Longer half-life allows prolonged enhancement of co-administered actives.
Overall PK Advantage of CardioActive®
- Higher peak plasma concentrations of CoQ10 & EGCG
- Extended half-life & bioavailability
- Improved tissue targeting (especially heart, vessels, liver)
- Reduced metabolism and slower clearance
- Synergistic enhancement of therapeutic exposure
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